Arava

Arava (leflunomide) is the first oral treatment approved for slowing the progression of rheumatoid arthritis. Although its effects are similar to those of methotrexate, this drug works by a different chemical mechanism that blocks at least one enzyme in certain immune cells called lymphocytes (a type of white blood cell that is part of the immune system), and thereby retards the progression of the disease.

However, Arava is not a cure for rheumatoid arthritis. It may cause birth defects, and the label carries a special warning for pregnant women and those planning to become pregnant. Liver damage, including deaths, also have been reported. The drug is not recommended for patients with severe immunodeficiency, bone marrow dysplasia, or severe, uncontrolled infections.

Special Warnings with Arava:

For Women:

• You must not take Arava if you are pregnant or a woman of childbearing age not using reliable contraception, because in animal studies Arava has been shown to cause birth defects to the fetus.
• You must avoid becoming pregnant while being treated with Arava. If you suspect or find out that you are pregnant while taking Arava call you health care provider right away.
• After stopping Arava treatment you must complete the drug elimination procedure before becoming pregnant because Arava stays in the body a long time.
• You should not breast-feed if you are taking Arava.

For Men:

• If there is any possibility your partner could become pregnant, you should stop Arava treatment and go through the drug elimination procedure prescribed by your doctor

For All Patients:

Your doctor will conduct liver tests before you start taking Arava and will check your liver's response to Arava every month at first.

General Precautions with Arava:

If you have the following conditions or if you are being treated with medications that can be harmful to your liver Arava may not be right for you:

• Liver disease including hepatitis B or C
• Kidney problems
• Severe immune system disorders, bone marrow disorders or severe uncontrolled infection.

Time Limits on Filing Suit
Every case has a statute of limitations that will apply. It varies by the type of case and the state where the case is filed. Don't wait until there is trouble or until the end of your case to get a lawyer. Your attorney would prefer to be involved every step of the way, to monitor your case, to guide you, to prevent trouble, and to assist you.

Irwin & Boesen represents persons who have been injured by dangerous drugs. Please contact us for an honest and fair evaluation of your case.